HCID 19014057, compound → HCID 19014054, compound

HRID 1728538Notes

Reaction equation

HRID 1728538 reaction equation
C([CH:5]([C:17]([OH:19])=[O:18])[O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](=[O:16])[CH3:15])[CH:10]=[CH:11][CH:12]=1)(C)(C)C>FC(F)(F)C(O)=O>[C:17]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](=[O:16])[CH3:15])[CH:10]=[CH:11][CH:12]=1)([OH:19])=[O:18]

Participants

3

Reactant 1

HCID 19014057HCID 19014057, compound

Product 1

HCID 19014054HCID 19014054, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

To m-(t-butylcarboxymethoxy)phenyl acetone, 6.7 g, was added trifluoroacetic acid (40 ml) at room temperature under nitrogen. After five minutes, reaction was found to be completed by tlc (silica gel eluted with 1:9 parts by volume methanol:methylene chloride) and the solvent was then evaporated to dryness. The resulting brown oil showed the desired product and trace of starting material on tlc. IR showed characteristic carboxylic acid peak at 3600-2450 cm-1.

Workup

  1. customreaction
  2. washto be completed by tlc (silica gel eluted with 1:9 parts by volume methanol:methylene chloride)
  3. customthe solvent was then evaporated to dryness

Sources & evidence

ORD record
ord-34af3a6a82bf4e8985c14aaaf35e4e9d
Source dataset
uspto-grants-1994_07
Patent number
US05328828

Reaction notes

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