Acetate → HCID 19014038, compound

HRID 1728541Notes

Reaction equation

HRID 1728541 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:19]=[CH:18][C:9]([C:10]([CH2:12][C:13]([O:15]CC)=[O:14])=O)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl.[NH2:21]O.CO.C([O-])(=O)C>O>[CH3:1][S:2]([NH:5][C:6]1[CH:19]=[CH:18][C:9]([C:10]2[CH2:12][C:13](=[O:14])[O:15][N:21]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:3]

Participants

6

Reactant 4

HCID 175AcetateHCID 887MethanolHCID 443297Hydroxyamine hydrochlorideHCID 13971553HCID 13971553, compound

Product 1

HCID 19014038HCID 19014038, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture 23.0 g of ethyl 4-methanesulfonamidobenzoylacetate, 5.8 g of hydroxylamine hydrochloride, and 35 ml of methanol, 8.2 g of pottasium acetate was added, and the mixture was refluxed for 30 minutes while being heated. The reaction mixture was poured into 210 ml of water, and the precipitated crystals were collected by filtering and dried, thereby obtaining 1.39 of 3-(4-methanesulfonamidophenyl)isoxazolin-5-one.

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperaturewhile being heated
  3. customthe precipitated crystals were collected
  4. filtrationby filtering
  5. customdried

Sources & evidence

ORD record
ord-6d769b1635214f639802f9ba0cbc4d41
Source dataset
uspto-grants-1994_07
Patent number
US05328818

Reaction notes

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