Methyl iodide → HCID 19014325, compound

HRID 1728556Notes

Reaction equation

[CH3:1]I.[CH3:3][C:4]1[C:12]2[C:11](=[O:13])[NH:10][CH:9]=[N:8][C:7]=2[N:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]=1[CH3:20]>>[CH3:1][N:10]1[C:11](=[O:13])[C:12]2[C:4]([CH3:3])=[C:5]([CH3:20])[N:6]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:7]=2[N:8]=[CH:9]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 135678188HCID 135678188, compound

Product 1

HCID 19014325HCID 19014325, compoundYield 62.4%

Procedure

The starting material was prepared as described in Example 3 by the alkylation with methyl iodide of 5,6-dimethyl-7-phenyl-3H,7H-pyrrolo-[2,3-d]pyrimidin-4-one (see US Patent 4,229,453). There was thus obtained 3,5,6-trimethyl-7-phenyl-3H-7H-pyrrolo-[2,3-d]pyrimidin-4-one (62.4% yield) m.p. 207°-208° C.; microanalysis, found: C, 71.0; H, 6.2; N, 16.3%; C15H15N3 requires C, 71.1; H, 5.97; N, 16.6%; NMR: CDCl3 ; 2.1(3H, s, CH3), 2.4-2.5(3H, s, CH3), 3.5-3.6(3H, s, N-CH3), 7.25-7.6(5H, complex, aromatic), 7.7-7.8(1H, s, C-H).

Workup

customThe starting material was prepared

Sources & evidence

ORD record: ord-a40c34da18794094acb887f1266b7b20
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05328910

Reaction notes

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