Hydrogen Bromide → HCID 178428167, compound

HRID 1728588Notes

Reaction equation

HRID 1728588 reaction equation
C[O:2][C:3]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:6]2=[N:7][CH:8]=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1.Br>O>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[C:6]2[N:12]([CH2:13][C:14]3[CH:15]=[CH:16][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]4[NH:27][N:28]=[N:29][N:30]=4)=[CH:18][CH:19]=3)[C:3](=[O:2])[NH:4][C:5]=12

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 178493972HCID 178493972, compound

Product 1

HCID 178428167HCID 178428167, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 90 mg (0.23 mmol) of 2-methoxy-7-methyl-3[(2'-(1H-tetrazol-5-yl) -biphenyl-4-yl)methyl]-3H-imidazo[4.5-b]pyridine and 1 ml of 48% HBr was stirred at a room temperature for 1.5 hours. The product mixture was mixed with water to produce crystals, which was taken out and washed with water to obtain 70 mg of the intended compound.

Workup

  1. customto produce crystals, which
  2. washwashed with water

Sources & evidence

ORD record
ord-0244d473bd0142cc8109725cfb561146
Source dataset
uspto-grants-1994_07
Patent number
US05328911

Reaction notes

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