Hydrochloric Acid → HCID 67842554, compound

HRID 1728598Notes

Reaction equation

HRID 1728598 reaction equation
[O:1]=[C:2]([CH2:8][CH2:9][CH3:10])[C:3]([O:5][CH2:6][CH3:7])=O.[N+:11]([C:14]1[CH:19]=[CH:18][C:17]([NH:20][NH2:21])=[CH:16][CH:15]=1)([O-:13])=[O:12].Cl>C(O)C>[N+:11]([C:14]1[CH:15]=[CH:16][C:17]([NH:20][N:21]=[C:3]([O:5][CH2:6][CH3:7])[C:2](=[O:1])[CH2:8][CH2:9][CH3:10])=[CH:18][CH:19]=1)([O-:13])=[O:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 123521Ethyl 2-oxovalerateHCID 3310889(4-Nitrophenyl)hydrazine

Product 1

HCID 67842554HCID 67842554, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the ester (D28) (0.53 g, 3.6 mM) in ethanol (20 ml) was added 4-nitrophenylhydrazine (0.56 g, 3.6 mM) and the suspension stirred for 0.5 h. Concentrated hydrochloric acid (2 ml) was added to give a brown solution. After stirring for 0.5 h the solution was cooled in ice and the precipitated title compound filtered off (0.72 g; 69%).

Workup

  1. customto give a brown solution
  2. stirringAfter stirring for 0.5 h the solution
  3. temperaturewas cooled in ice
  4. customthe precipitated title compound
  5. filtrationfiltered off (0.72 g; 69%)

Sources & evidence

ORD record
ord-481722cc23624514887ab3749cff054d
Source dataset
uspto-grants-1994_07
Patent number
US05328922

Reaction notes

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