Phosgene → 143797-64-2

HRID 1728604Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH3:12])=[C:5]2[CH3:13].[C:14](Cl)([Cl:16])=[O:15].[NH2:18][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1>>[ClH:16].[CH3:11][N:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:14]([NH:18][C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[O:15])=[CH:10][CH:9]=2)[C:5]([CH3:13])=[C:6]1[CH3:12]

Participants

Reactant 3

HCID 6371Phosgene

HCID 100093-Aminopyridine

HCID 64959931,2,3-Trimethyl-1H-indol-5-ylamine

Product 1

HCID 19016514143797-64-2Yield 51%

Procedure

The title compound was prepared in 51% yield from 5-amino-1,2,3-trimethyl-1H-indole (D6), phosgene and 3-aminopyridine using a procedure similar to that in Example 1, m.p. 330° C.

Sources & evidence

ORD record: ord-fd46c47d05d84cf491b5f37ddfa2093f
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05328922

Reaction notes

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