4-Aminopyridine → HCID 67842562, compound

HRID 1728610Notes

Reaction equation

HRID 1728610 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH3:12])=[C:5]2[CH2:13][CH3:14].[C:15](Cl)([Cl:17])=[O:16].[NH2:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1>>[ClH:17].[CH3:11][N:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:15]([NH:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[O:16])=[CH:10][CH:9]=2)[C:5]([CH2:13][CH3:14])=[C:6]1[CH3:12]

Participants

4

Reactant 3

HCID 17274-AminopyridineHCID 6371PhosgeneHCID 19016521HCID 19016521, compound

Product 1

HCID 67842562HCID 67842562, compoundYield 47%

Procedure

The title compound was prepared in 47% yield from the aminoindole (D1), phosgene and 4-aminopyridine using a procedure similar to that described for Example 1, the product being isolated as the hydrochloride salt, m.p. 237°-243° C.

Sources & evidence

ORD record
ord-a2ed9be053744d22b65c1e7acdfc65a2
Source dataset
uspto-grants-1994_07
Patent number
US05328922

Reaction notes

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