1-Iodopropane → HCID 131718549, compound

HRID 1728659Notes

Reaction equation

HRID 1728659 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:28])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][NH:13][CH2:12][C@H:11]2[CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:6][CH:5]=1.I[CH2:30][CH2:31][CH3:32].Cl.CN(C)C1C=CC([C@@H]2CCN(CC)C[C@H]2COC2C=CC(C(F)(F)F)=CC=2)=CC=1>C(O)C>[ClH:1].[CH3:2][N:3]([CH3:28])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][N:13]([CH2:30][CH2:31][CH3:32])[CH2:12][C@H:11]2[CH2:16][O:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 336431-IodopropaneHCID 131718545HCID 131718545, compoundHCID 131718547HCID 131718547, compound

Product 1

HCID 131718549HCID 131718549, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation from (41) (0.35 g) and 1-iodopropane (0.2 ml) by heating in ethanol of 70° C. for 8 h, as described for compound (42). Yield 37%, m.p. 224.2°-225.2° C.

Sources & evidence

ORD record
ord-e195c9d44566439aab0e8027bdfe406e
Source dataset
uspto-grants-1994_07
Patent number
US05328917

Reaction notes

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