Bromocyclopentane → HCID 131718554, compound

HRID 1728662Notes

Reaction equation

HRID 1728662 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:28])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][NH:13][CH2:12][C@H:11]2[CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:6][CH:5]=1.Br[CH:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1.C([O-])([O-])=O.[K+].[K+]>>[ClH:1].[CH:30]1([N:13]2[CH2:14][CH2:15][C@@H:10]([C:7]3[CH:8]=[CH:9][C:4]([N:3]([CH3:28])[CH3:2])=[CH:5][CH:6]=3)[C@H:11]([CH2:16][O:17][C:18]3[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=3)[CH2:12]2)[CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

4

Reactant 3

HCID 8728BromocyclopentaneHCID 11430Potassium CarbonateHCID 131718545HCID 131718545, compound

Product 1

HCID 131718554HCID 131718554, compound

Procedure

Prepared from (41) (1.5 g), bromocyclopentane (0.80 g) and K2CO3 (1 g). Reflux for 21 h. Purification of the crude product on silica gel column. Yield of (68) 11%. M.p. 205.8°-206.2° C.

Workup

  1. temperatureReflux for 21 h
  2. customPurification of the crude product on silica gel column

Sources & evidence

ORD record
ord-45d9816b5521409fa34dcdc1c8cce30e
Source dataset
uspto-grants-1994_07
Patent number
US05328917

Reaction notes

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