1-Bromo-3-methylbutane → HCID 131718556, compound

HRID 1728663Notes

Reaction equation

HRID 1728663 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:28])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][NH:13][CH2:12][C@H:11]2[CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:6][CH:5]=1.[CH3:29][CH:30]([CH3:34])[CH2:31][CH2:32]Br.C([O-])([O-])=O.[K+].[K+]>>[ClH:1].[CH3:2][N:3]([CH3:28])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[CH2:15][CH2:14][N:13]([CH2:32][CH2:31][CH:30]([CH3:34])[CH3:29])[CH2:12][C@H:11]2[CH2:16][O:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 78911-Bromo-3-methylbutaneHCID 11430Potassium CarbonateHCID 131718545HCID 131718545, compound

Product 1

HCID 131718556HCID 131718556, compound

Procedure

Prepared from (41) (0.5 g), 3-methyl-1-bromobutane (0.4 g) and K2CO3 (0.5 g). Reflux for 8 h. Purification on silica gel. Yield of (69) 51%. M.p. 223.9°-225.1° C.

Workup

  1. temperatureReflux for 8 h
  2. customPurification on silica gel

Sources & evidence

ORD record
ord-6656c6ec4ba548219343852d1b272cd8
Source dataset
uspto-grants-1994_07
Patent number
US05328917

Reaction notes

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