反应详情

To a 0° C. solution of 2.3 g of product from Example 87 in 50 ml of methylene chloride is added, dropwise, 0.72 g of 2-(2-aminoethyl)pyridine followed by 1.77 g of pyridine. The reaction is stirred at room temperature for 16 hours, poured into chloroform and saturated sodium bicarbonate and extracted with chloroform. The combined chloroform layers are washed with saturated sodium chloride, dried and concentrated in vacuo. The residue is purified by column chromatography (silica gel: 75% ethyl acetate/hexane) to give 2.2 g of the desired product as a colorless solid.

1. extractionextracted with chloroform
2. washThe combined chloroform layers are washed with saturated sodium chloride
3. customdried
4. concentrationconcentrated in vacuo
5. customThe residue is purified by column chromatography (silica gel: 75% ethyl acetate/hexane)