Sodium Hydroxide → L-(-)-Ornithine

HRID 1729009Notes

Reaction equation

HRID 1729009 reaction equation
Cl.[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7].[OH-].[Na+]>O>[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 76654Ornithine hydrochloride

Product 1

HCID 6262L-(-)-OrnithineYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ornithine hydrochloride (16.8 g, 0.1 mole) was dissolved in water (20 mL), to which was added sodium hydroxide (4 g, 0.1 mole) . After completely evaporating the water using a freeze drier, methanol (100 mL) was added, and the suspension was stirred at room temperature overnight, then filtered. The clear methanol filtrate was concentrated slowly under vacuumto about 10 mL to a white slurry and solid. The white solid was collected and air dried to give ornithine (9.2 g, 70%).

Workup

  1. customAfter completely evaporating the water using a freeze drier
  2. additionmethanol (100 mL) was added
  3. filtrationfiltered
  4. concentrationThe clear methanol filtrate was concentrated slowly
  5. customThe white solid was collected
  6. customair dried

Sources & evidence

ORD record
ord-720eb7433c0548a5b4c755b95d6d6c78
Source dataset
uspto-grants-1994_07
Patent number
US05330741

Reaction notes

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