2-Chloropyrimidine-4-carboxamide → HCID 15233813, compound

HRID 1729027Notes

Reaction equation

HRID 1729027 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5]([C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH:13][CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH:20]([CH2:23][O:24][C:25]3[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:26]=3[CH:32]([CH3:34])[CH3:33])[CH2:19][CH2:18]2)[N:8]=1)=[O:6].Cl[C:36]1[N:41]=[C:40]([C:42]([NH2:44])=[O:43])[CH:39]=[CH:38][N:37]=1.[K]>C(#N)C>[NH2:44][C:42]([C:40]1[CH:39]=[CH:38][N:37]=[C:36]([NH:1][CH2:2][CH2:3][NH:4][C:5]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][CH2:21][CH:20]([CH2:23][O:24][C:25]4[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:26]=4[CH:32]([CH3:34])[CH3:33])[CH2:19][CH2:18]3)[N:8]=2)=[O:6])[N:41]=1)=[O:43]

Participants

5

Reactant 3

HCID 2470282-Chloropyrimidine-4-carboxamideHCID 5462222PotassiumHCID 19013273HCID 19013273, compound

Product 1

HCID 15233813HCID 15233813, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2.31 g (4.92 mmol) of N-(2-aminoethyl)-2-[[3-[4-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]piperidin-1-yl]propyl]amino]pyrimidine-4-carboxamide, 0.82 g (5.2 mmol) of 2-chloropyrimidine-4-carboxamide, 0.89 g (6.4 mmol) of potassium carbonateand 75 ml of acetonitrile are introduced, under an argon atmosphere, into a0.25 l round-bottomed flask and the mixture is heated at reflux for 30 h.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 30 h.

Sources & evidence

ORD record
ord-15e83985fbd34334a411c0ed74d262e4
Source dataset
uspto-grants-1994_07
Patent number
US05330985

Reaction notes

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