反应详情

A reaction mixture of 4-(hydroxymethyl)-quinoline hydrobromide (2.0 g, 12.6mmol) and thionylchloride (20 mL) was heated to reflux for 2 hours. This was allowed to cool and then concentrated in vacuum. The green solid was treated with ethyl ether, filtered, washed with ethyl ether and dried in vacuum to yield 4-(chloromethyl)-quinoline hydrochloride (2.17 g, 80.7%).

1. temperaturewas heated
2. temperatureto reflux for 2 hours
3. temperatureto cool
4. concentrationconcentrated in vacuum
5. additionThe green solid was treated with ethyl ether
6. filtrationfiltered
7. washwashed with ethyl ether
8. customdried in vacuum