HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Chloromethyl)quinoline--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Quinolin-4-ylmethanol hydrobromide | HCID 19013536 | — |
| Product | 4-(Chloromethyl)quinoline--hydrogen chloride (1/1) | HCID 23001619 | 80.7% |
Reaction Steps
A reaction mixture of 4-(hydroxymethyl)-quinoline hydrobromide (2.0 g, 12.6mmol) and thionylchloride (20 mL) was heated to reflux for 2 hours. This was allowed to cool and then concentrated in vacuum. The green solid was treated with ethyl ether, filtered, washed with ethyl ether and dried in vacuum to yield 4-(chloromethyl)-quinoline hydrochloride (2.17 g, 80.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05331006 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-9b6a0e8d643b48079adb7a744577a24d |
| Source note | uspto-grants-1994_07 |