反应详情

温度

40 °C

According to the same method as in Reference Example 31, 2-amino-4-bromo-5-iodo-3-methoxy-6-methylbenzoic acid (I-4) (3.42 g, 8.86 mmol) and bis(trichloromethyl) carbamate (893 mg, 3.01 mmol) were dissolved in dewatered tetrahydrofuran (70 ml) under nitrogen atmosphere, followed by stirring at 40° C. for 1 hour. The reaction liquid was concentrated under reduced pressure to obtain the entitled compound (3.89 g, quant.) as a pale brown solid. Not further purified, this was used in the next reaction.

1. customThe reaction liquid
2. concentrationwas concentrated under reduced pressure
3. customto obtain the entitled compound (3.89 g, quant.) as a pale brown solid
4. customNot further purified
5. customthis was used in the next reaction