Lithium hydroxide, monohydrate → HCID 54537628, compound

HRID 1729104Notes

Reaction equation

HRID 1729104 reaction equation
C[N:2]([C:23]([O:25][C:26]12[CH2:35][CH:30]3[CH2:31][CH:32]([CH2:34][CH:28]([CH2:29]3)[CH2:27]1)[CH2:33]2)=[O:24])[C:3]([CH3:22])([C:19]([OH:21])=[O:20])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.O.[OH-].[Li+]>>[CH3:22][C:3]([C:19]([OH:21])=[O:20])([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[NH:2][C:23]([O:25][C:26]12[CH2:27][CH:28]3[CH2:29][CH:30]([CH2:31][CH:32]([CH2:34]3)[CH2:33]1)[CH2:35]2)=[O:24]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 86747987HCID 86747987, compound

Product 1

HCID 54537628HCID 54537628, compound

Procedure

The title compound was prepared from methyl α-methyl-O-(phenylmethyl)-N-[(tricyclo[3.3.1.13,7 ]dec-1-yloxy)carbonyl]-DL-tyrosine (200 mg, 0.418 mmol) and lithium hydroxide monohydrate (26.3 mg, 0.628 mmol, 1.5 eq) using the procedure described in Example 47, Step C.

Sources & evidence

ORD record
ord-5b6924b7e185429bad6dfe61b6bb1ad4
Source dataset
uspto-grants-1994_07
Patent number
US05331006

Reaction notes

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