反应详情

33.0 g (0.1 mol) of benzyl 4'-acetyl-4-biphenylcarboxylate, 200 ml of tetrahydrofuran and 50 ml of ethanol were supplied into a four-necked flask provided with a stirrer and a thermometer. Then 3.8 g (0.1 mol) of sodium borohydride was added at 15°-25° C. over a period of 10 minutes. The mixture was maintained at the same temperature for 2 hours. The reaction mixture was poured into ice-water and extracted twice with 300 ml of chloroform. The organic layer was washed with water and concentrated under reduced pressure to obtain 32.9 g (99% yield) of benzyl 4'-(1-hydroxyethyl)-4-biphenylcarboxylate (III-25).

1. customprovided with a stirrer
2. temperatureThe mixture was maintained at the same temperature for 2 hours
3. extractionextracted twice with 300 ml of chloroform
4. washThe organic layer was washed with water
5. concentrationconcentrated under reduced pressure