Triethylamine → HCID 495678, compound

Participants

Reaction Steps

1.1 equivalents of triethylamine are added to 4.5 g (0.016 mol) of the 4-hydroxy-1-[3,4-methylenedioxybenzoyl]pyrrolidine-2-carboxylic acid obtained in Example 5 suspended in 130 ml of acetonitrile at 0° C. The reaction mixture is stirred for 20 minutes and then 1.1 equivalents of ethyl chloroformate are added while maintaining the temperature between 0° and 5° C. After stirring for 20 minutes, ammonia is bubbled through the reaction mixture. The precipitate formed is separated. The filtrate is removed under vacuum, the precipitate obtained is recrystallized in acetonitrile.

Provenance & Evidence