1-(2-Methoxyphenyl)piperazine → Piperazine, 1-(4-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)butyl)-4-(2-methoxyphenyl)-

HRID 1729223Notes

Reaction equation

HRID 1729223 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[S:15][CH2:14][CH2:13][CH2:12]2.C(N(CC)C(C)C)(C)C.[CH3:26][O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>C(#N)C>[CH3:26][O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[N:34]1[CH2:39][CH2:38][N:37]([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:16]=2[S:15][CH2:14][CH2:13][CH2:12]3)[CH2:36][CH2:35]1

Participants

5

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 81531DiisopropylethylamineHCID 15295829HCID 15295829, compound

Product 1

HCID 3073901Piperazine, 1-(4-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)butyl)-4-(2-methoxyphenyl)-

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent3×

Procedure

1.5 g (4.98 mmol) of the compound obtained in Step A are dissolved in 15 cm3 of acetonitrile, under argon. 0.94 g (7.47 mmol) of N,N-diisopropylethylamine diluted in 11 cm3 of acetonitrile is added, followed by 1.44 g (0.747 mmol) of 1-(2-methoxyphenyl)piperazine dissolved in 11 cm3 of acetonitrile.

Workup

  1. additionis added

Sources & evidence

ORD record
ord-6b91aae94e724095af5d9355682c8dea
Source dataset
uspto-grants-1994_07
Patent number
US05332741

Reaction notes

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