Ethyl Acrylate → HCID 14896448, compound

HRID 1729251Notes

Reaction equation

HRID 1729251 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[NH2:8][CH:9]1[C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2>C(O)C.C(Cl)Cl>[CH2:6]([O:5][C:1](=[O:4])[CH2:2][CH2:3][NH:8][CH:9]1[C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH3:7]

Participants

5

Reactant 2

HCID 8821Ethyl AcrylateHCID 10671Fluoren-9-amine

Product 1

HCID 14896448HCID 14896448, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

1.0 ml of ethyl acrylate was added to a solution of 9-aminofluorene (1.24 g) in ethanol (20 ml). The resultant mixture was stirred at 80° C. for 5 hours and, then, at room temperature for 36 hours. The residue obtained by condensing the reaction mixture was dissolved in methylene chloride and, then, washed with saturated saline, dried over anhydrous magnesium sulfate, and concentrated. The residue was purified by a silica gel column chromatography (eluting solution: methylene chloride-ether) to give 1.25 g of N-(9-fluorenyl)-β-alanine ethyl ester.

Workup

  1. customThe residue obtained by condensing the reaction mixture
  2. washwashed with saturated saline
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated
  5. customThe residue was purified by a silica gel column chromatography (eluting solution: methylene chloride-ether)

Sources & evidence

ORD record
ord-b94eb54e10354d5a994f898e58cdcfcc
Source dataset
uspto-grants-1994_07
Patent number
US05332734

Reaction notes

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