反应详情

3 ml of triethylamine was added to 10 ml of an ethanol solution containing 2.5 g of 3-(4-chlorophenoxy)propyl bromide and 1.3 g of 1,3-dimethyl-6-(1-piperazinyl)-2,4(1H,3H)-pyrimidinedione, and the solution was then heated under reflux for 3 hours. Afterward, the reaction solution was concentrated to dryness, and the resultant residue was dissolved in chloroform and then washed with water. The thus obtained chloroform solution was dried and then concentrated, and the residue was recrystallized from ethanol/hexane, thereby preparing 1.96 g (yield: 86%) of 6-[4-(3-[4-chlorophenoxy]propyl)piperazin-1-yl]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione.

1. temperaturethe solution was then heated
2. temperatureunder reflux for 3 hours
3. concentrationAfterward, the reaction solution was concentrated to dryness
4. dissolutionthe resultant residue was dissolved in chloroform
5. washwashed with water
6. dry with materialThe thus obtained chloroform solution was dried
7. concentrationconcentrated
8. customthe residue was recrystallized from ethanol/hexane