Methylamine → HCID 15937813, compound

HRID 1729292Notes

Reaction equation

HRID 1729292 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1.[CH3:16][NH2:17]>O>[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([NH:17][CH3:16])(=[O:14])=[O:13])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 22101224HCID 22101224, compound

Product 1

HCID 15937813HCID 15937813, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.4 g of 4-(3-bromopropoxy)benzenesulfonic acid chloride was suspended in water, and 6.2 ml a 20% aqueous methylamine solution was added to the suspension under ice cooling. The solution was stirred at room temperature for 2 hours and then extracted with chloroform (50 ml×2), and drying and concentration followed to obtain 2.9 g (yield: 87%) of 4-(3-bromopropoxy)-N-methylbenzenesulfonamide in an oily state.

Workup

  1. extractionextracted with chloroform (50 ml×2)
  2. customdrying
  3. concentrationconcentration

Sources & evidence

ORD record
ord-4b7e2278753a44a388edab328dd8da47
Source dataset
uspto-grants-1994_07
Patent number
US05332739

Reaction notes

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