Piperazine → 1-(3-Phenoxypropyl)piperazine

HRID 1729295Notes

Reaction equation

HRID 1729295 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>O1CCOCC1>[O:1]([CH2:8][CH2:9][CH2:10][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 68522Benzene, (3-bromopropoxy)-

Product 1

HCID 27603511-(3-Phenoxypropyl)piperazineYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

15.1 g of phenoxypropyl bromide and 60 g of piperazine were dissolved in 150 ml of dioxane, and the solution was heated at 80°-90° C. for 1 hour. The precipitated crystals were removed by filtration, and the filtrate was then concentrated. Afterward, the resultant residue was dissolved in chloroform and then washed with water. Chloroform was distilled off to obtain 15 g of 1-(3-phenoxypropyl)piperazine.

Workup

  1. temperaturethe solution was heated at 80°-90° C. for 1 hour
  2. customThe precipitated crystals were removed by filtration
  3. concentrationthe filtrate was then concentrated
  4. dissolutionAfterward, the resultant residue was dissolved in chloroform
  5. washwashed with water
  6. distillationChloroform was distilled off

Sources & evidence

ORD record
ord-9c2bc073c8994a39952be9abbaa1f69a
Source dataset
uspto-grants-1994_07
Patent number
US05332739

Reaction notes

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