4-Chlorophenol → HCID 19011882, compound

HRID 1729307Notes

Reaction equation

HRID 1729307 reaction equation
[Cl:1]C1C=CC(O)=CC=1.ClC1C=C(O)C=C(Cl)C=1.[CH3:18][N:19]1[C:24]([N:25]2[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][CH2:33][O:34][C:35]3[CH:40]=[C:39]([Cl:41])[CH:38]=[C:37]([Cl:42])[CH:36]=3)[CH2:27][CH2:26]2)=[CH:23][C:22](=[O:43])[N:21]([CH3:44])[C:20]1=[O:45]>>[ClH:1].[CH3:18][N:19]1[C:24]([N:25]2[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][CH2:33][O:34][C:35]3[CH:40]=[C:39]([Cl:41])[CH:38]=[C:37]([Cl:42])[CH:36]=3)[CH2:27][CH2:26]2)=[CH:23][C:22](=[O:43])[N:21]([CH3:44])[C:20]1=[O:45]

Participants

4

Reactant 3

HCID 46844-ChlorophenolHCID 115713,5-DichlorophenolHCID 19011883HCID 19011883, compound

Product 1

HCID 19011882HCID 19011882, compound

Procedure

The same treatment as in Example 3 was effected except that 4-chlorophenol was replaced with 3,5-dichlorophenol, thereby obtaining 12.5 g of the crystals of 1,3-dimethyl-6-[4-(3-[3,5-dichlorophenoxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.

Sources & evidence

ORD record
ord-ca95fa13dfff4a439d57c86efa3c8ad0
Source dataset
uspto-grants-1994_07
Patent number
US05332739

Reaction notes

Loading…