HCID 19011821, compound → HCID 19012147, compound

HRID 1729317Notes

Reaction equation

[CH3:1][N:2]1[C:7]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=3)[CH2:10][CH2:9]2)=[CH:6][C:5](=[O:28])[N:4]([CH3:29])[C:3]1=[O:30].[ClH:31].CO>>[ClH:31].[CH3:1][N:2]1[C:7]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]3[CH:18]=[CH:19][C:20]([NH:23][S:24]([CH3:27])(=[O:25])=[O:26])=[CH:21][CH:22]=3)[CH2:10][CH2:9]2)=[CH:6][C:5](=[O:28])[N:4]([CH3:29])[C:3]1=[O:30]

Participants

Reactant 2

HCID 19011821HCID 19011821, compound

HCID 21893726Hydrochloride methanol

Product 1

HCID 19012147HCID 19012147, compound

Procedure

The Compound x obtained in Reference Example 19 was hydrogenated in the same manner as in Example 6 and then methane-sulfonated in the same manner as in Example 7 to obtain the crystals of 1,3-dimethyl-6-[4-(2-[4-methanesulfonamidophenoxy]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione. This pyrimidinedione derivative was treated with a hydrochloric acid/methanol solution in an ordinary manner to obtain the crystals of 1,3-dimethyl-6-[4-(2-[4-methanesulfonamidophenoxy]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.hydrochloride (Compound 136).

Sources & evidence

ORD record: ord-2920c2ee00be4588bca31c3ab25b8ff2
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332739

Reaction notes

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