HCID 19011821, compound → HCID 19012147, compound

Participants

Reaction Steps

The Compound x obtained in Reference Example 19 was hydrogenated in the same manner as in Example 6 and then methane-sulfonated in the same manner as in Example 7 to obtain the crystals of 1,3-dimethyl-6-[4-(2-[4-methanesulfonamidophenoxy]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione. This pyrimidinedione derivative was treated with a hydrochloric acid/methanol solution in an ordinary manner to obtain the crystals of 1,3-dimethyl-6-[4-(2-[4-methanesulfonamidophenoxy]ethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.hydrochloride (Compound 136).

Provenance & Evidence