Hydrochloric Acid → HCID 19012392, compound

HRID 1729334Notes

Reaction equation

HRID 1729334 reaction equation
[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]([O:26]C)=[O:25])=[CH:14][CH:13]=2)[C:9](=[O:28])[C:8]([CH2:29][C:30]#[N:31])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-:32].[K+].Cl>>[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]([OH:26])=[O:25])=[CH:14][CH:13]=2)[C:9](=[O:28])[C:8]([CH2:29][C:30](=[O:32])[NH2:31])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19012350HCID 19012350, compound

Product 1

HCID 19012392HCID 19012392, compound

Procedure

A mixture of 400 mg of 6-butyl-3-cyanomethyl-1-(2'-methoxycarbonylbiphenyl-4-ylmethyl)-1,2-dihydro-2-oxopyridine and 2.2 ml of 1N aqueous KOH solution is boiled for 3 hours, cooled and acidified with hydrochloric acid. 6-Butyl-3-carbamoylmethyl-1-(2'-carboxybiphenyl-4-ylmethyl)-1,2-dihydro-2-oxopyridine is obtained after conventional working-up.

Workup

  1. temperaturecooled

Sources & evidence

ORD record
ord-137d9519a996448eaa29055d92193048
Source dataset
uspto-grants-1994_07
Patent number
US05332750

Reaction notes

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