HCID 19012343, compound → HCID 19012340, compound

HRID 1729336Notes

Reaction equation

HRID 1729336 reaction equation
[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[N+:24]([O-])=O)=[CH:14][CH:13]=2)[C:9](=[O:27])[CH:8]=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]>C(O)C.[Ni]>[NH2:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:15]1[CH:16]=[CH:17][C:12]([CH2:11][N:10]2[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[CH:6][CH:7]=[CH:8][C:9]2=[O:27])=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 19012343HCID 19012343, compound

Product 1

HCID 19012340HCID 19012340, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 1 g of 6-butyl-1-(2'-nitrobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxopyridine in 30 ml of ethanol is hydrogenated on 1 g of Raney Ni at 20° until the uptake of H2 has ceased. The mixture is filtered and evaporated to give 1-(2'-aminobiphenyl-4-ylmethyl)-6-butyl-1,2-dihydro-2-oxopyridine.

Workup

  1. filtrationThe mixture is filtered
  2. customevaporated

Sources & evidence

ORD record
ord-3356f3086a15476db42bfcec7922f97d
Source dataset
uspto-grants-1994_07
Patent number
US05332750

Reaction notes

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