Hydroxyamine hydrochloride → HCID 18654049, compound

HRID 1729349Notes

Reaction equation

[Br:1][C:2]1[N:3]=[C:4]([C:17]2([O:23][CH3:24])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[S:5][C:6]=1[S:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][CH:9]=1.Cl.[NH2:26][OH:27]>>[Br:1][C:2]1[N:3]=[C:4]([C:17]2([O:23][CH3:24])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[S:5][C:6]=1[S:7][C:8]1[CH:13]=[CH:12][C:11](/[C:14](=[N:26]/[OH:27])/[CH3:15])=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996192HCID 18996192, compound

Product 1

HCID 18654049HCID 18654049, compoundYield 96%

Procedure

Using an analogous procedure to that described in Example 15, 4'-[4-bromo-2-(4-methoxytetrahydropyran-4-yl)thiazol-5-ylthio]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[4-bromo-2-(4-methoxytetrahydropyran-4-yl)thiazol-5-ylthio]acetophenone oxime in 96% yield, m.p. 130° C.;

Sources & evidence

ORD record: ord-e6abaa2967aa4eec913caa84b3584e98
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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