Hydroxyamine hydrochloride → HCID 18654055, compound

HRID 1729355Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:20]2([O:26][CH3:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH3:16])=[C:11]([O:18][CH3:19])[CH:10]=2)[CH:7]=1.Cl.[NH2:29][OH:30]>>[F:1][C:2]1[CH:3]=[C:4]([C:20]2([O:26][CH3:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12](/[C:15](=[N:29]/[OH:30])/[CH3:16])=[C:11]([O:18][CH3:19])[CH:10]=2)[CH:7]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996273HCID 18996273, compound

Product 1

HCID 18654055HCID 18654055, compoundYield 52%

Procedure

Using an analogous procedure to that described in Example 7, 4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-2'-methoxyacetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-2'-methoxyacetophenone oxime in 52% yield, m.p. 155° C.;

Sources & evidence

ORD record: ord-dae0ea81855a4b7d9ccea674864bac72
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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