Hydroxyamine hydrochloride → HCID 18996166, compound

HRID 1729366Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:21]2([O:27][CH3:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[CH:5]=[C:6]([S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[C:16](=O)[CH2:15][CH2:14]3)(=[O:10])=[O:9])[CH:7]=1.Cl.[NH2:30][OH:31]>>[F:1][C:2]1[CH:3]=[C:4]([C:21]2([O:27][CH3:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[CH:5]=[C:6]([S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)/[C:16](=[N:30]/[OH:31])/[CH2:15][CH2:14]3)(=[O:10])=[O:9])[CH:7]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996100HCID 18996100, compound

Product 1

HCID 18996166HCID 18996166, compoundYield 49%

Procedure

Using an analogous procedure to that described in Example 50, 5-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylsulphonyl]indan-1-one was reacted with hydroxylamine hydrochloride to give (E)-5-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylsulphonyl]indan-1-one oxime in 49% yield, m.p. 225°-226° C.;

Sources & evidence

ORD record: ord-18d008e6fb634b9489ee2f29de9e8551
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

Loading…