Hydroxyamine hydrochloride → HCID 88410184, compound

HRID 1729369Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:18]2([O:24][CH3:25])[CH2:22][CH2:21][O:20][CH:19]2[CH3:23])[CH:5]=[C:6]([CH:17]=1)[O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][CH:9]=1.Cl.[NH2:27][OH:28]>>[F:1][C:2]1[CH:3]=[C:4]([C:18]2([O:24][CH3:25])[CH2:22][CH2:21][O:20][CH:19]2[CH3:23])[CH:5]=[C:6]([CH:17]=1)[O:7][C:8]1[CH:13]=[CH:12][C:11](/[C:14](=[N:27]/[OH:28])/[CH3:15])=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996167HCID 18996167, compound

Product 1

HCID 88410184HCID 88410184, compoundYield 42%

Procedure

Using an analogous procedure to that described in Example 66, 4'-{5-fluoro-3-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]phenoxy}acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-{5-fluoro-3-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]phenoxy}acetophenone oxime in 42% yield, m.p. 126°-127° C.

Sources & evidence

ORD record: ord-aa9dd4c012fd4d1cbfb850624d0f8217
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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