Hydroxyamine hydrochloride → HCID 18996188, compound

HRID 1729375Notes

Reaction equation

[CH3:1][C:2]1([CH3:25])[O:6][C:5]([C:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:23]=[C:22]4[C:17]([C:18](=O)[CH2:19][CH2:20][O:21]4)=[CH:16][CH:15]=3)[S:11][CH:12]=2)([CH3:7])[CH2:4][O:3]1.Cl.[NH2:27][OH:28]>>[CH3:1][C:2]1([CH3:25])[O:6][C:5]([C:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:23]=[C:22]4[C:17](/[C:18](=[N:27]/[OH:28])/[CH2:19][CH2:20][O:21]4)=[CH:16][CH:15]=3)[S:11][CH:12]=2)([CH3:7])[CH2:4][O:3]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996170HCID 18996170, compound

Product 1

HCID 18996188HCID 18996188, compoundYield 65%

Procedure

Using an analogous procedure to that described in Example 68, 7-[4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-ylthio]chroman-4-one was reacted with hydroxylamine hydrochloride to give (E)-7-[4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-ylthio]chroman-4-one oxime in 65% yield as a gum.

Sources & evidence

ORD record: ord-d943901dc99240a4b197604d9105c3e8
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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