Hydroxyamine hydrochloride → HCID 86748013, compound

HRID 1729385Notes

Reaction equation

[Cl:1][C:2]1[CH:9]=[C:8]([S:10][C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([C:18]3([O:24][CH3:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:12]=2)[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:27][OH:28]>>[Cl:1][C:2]1[CH:9]=[C:8]([S:10][C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([C:18]3([O:24][CH3:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:12]=2)[CH:7]=[CH:6][C:3]=1[CH:4]=[N:27][OH:28]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996263HCID 18996263, compound

Product 1

HCID 86748013HCID 86748013, compoundYield 83%

Procedure

Using an analogous procedure to that described in Example 68, 2-chloro-4-[5-fluoro-3-(4-methoxytetrahydropyran-4yl)phenylthio]benzaldehyde was reacted with hydroxylamine hydrochloride to give 2-chloro-4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]benzaldehyde oxime in 83% yield as a gum.

Sources & evidence

ORD record: ord-e0e7e808db0e4ec884d11b3d20dee2c4
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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