Hydroxyamine hydrochloride → HCID 18654053, compound

HRID 1729388Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:20]2([O:26][CH3:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH:5]=[C:6]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17](=O)[CH3:18])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:7]=1.Cl.[NH2:29][OH:30]>>[F:1][C:2]1[CH:3]=[C:4]([C:20]2([O:26][CH3:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH:5]=[C:6]([S:8]([C:11]2[CH:16]=[CH:15][C:14](/[C:17](=[N:29]/[OH:30])/[CH3:18])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:7]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996249HCID 18996249, compound

Product 1

HCID 18654053HCID 18654053, compoundYield 83%

Procedure

Using an analogous procedure to that described in Example 50, 4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylsulphonyl]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylsulphonyl]acetophenone oxime in 83% yield, m.p. 180°-181° C.;

Sources & evidence

ORD record: ord-d936c4be01eb4f6981dfa578ce789879
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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