Hydroxyamine hydrochloride → HCID 10406486, compound

HRID 1729392Notes

Reaction equation

[CH3:1][C:2]1([CH3:23])[O:6][C@:5]([C:8]2[S:12][C:11]([S:13][C:14]3[CH:19]=[CH:18][C:17]([C:20](=O)[CH3:21])=[CH:16][CH:15]=3)=[N:10][CH:9]=2)([CH3:7])[CH2:4][O:3]1.Cl.[NH2:25][OH:26]>>[CH3:1][C:2]1([CH3:23])[O:6][C@:5]([C:8]2[S:12][C:11]([S:13][C:14]3[CH:19]=[CH:18][C:17](/[C:20](=[N:25]/[OH:26])/[CH3:21])=[CH:16][CH:15]=3)=[N:10][CH:9]=2)([CH3:7])[CH2:4][O:3]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 10247254HCID 10247254, compound

Product 1

HCID 10406486HCID 10406486, compoundYield 82%

Procedure

Using an analogous procedure to that described in Example 68, 4'-{5-[(4R)-2,2,4-trimethyl-1,3-dioxolan-4-yl]thiazol-2-ylthio}acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-{5-[(4R)-2,2,4-trimethyl-1,3-dioxolan-4-yl]thiazol-2-ylthio}acetophenone oxime in 82% yield as a gum.

Sources & evidence

ORD record: ord-49e50fad948744bea50142ef8e00908e
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05332757

Reaction notes

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