反应详情

2-butyl-3-[(2'-tert-butoxycarbonylbiphen-4-yl)methyl]-2-butyl-3H-imidazo[4,5-c]pyridine was prepared according to the procedure described in Example 1, Part A from 2-butylimidazo[4,5-c]pyridine (220 mg, 1.25 mmol), tert-butyl 4'-bromomethylbiphenyl-2-carboxylate (414 mg, 1.19 mmol), and NaH (1.88 mmol). Yield: 25 mg (5%) thick oil; Rf: 0.45 (SiO2 tlc, 1% MeOH/EtOAc); 1H NMR (250 MHz, CDCl3) δ 8.66 (s 1H), 8.42 (d, 1H, J=5.6 Hz), 7.78 (dd, 1H, J=7.5 1.4 Hz), 7.66 (d, 1H, J=5.5 Hz), 7.52-7.35 (m, 2H) 7.31-7.24 (m, 3H), 7.10 (d, 2H, J=8 Hz), 5.46 (s, 2H), 2.92 (t, 2H, J=7.5 Hz), 1.97- 1.80 (m, 2H), 1.55-1.39 (m, 2H), 1.21 (s, 9H), 0.96 (t, 3H, J=7.3 Hz).