2,6-Dimethyl-8-ethyl-1-deazapurine → Hydrochloric Acid

HRID 1729452Notes

Reaction equation

HRID 1729452 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([CH2:11][CH3:12])[NH:10][C:5]2=[C:4]([CH3:13])[CH:3]=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:21]2[C:25]([C:26]3[C:31]([C:32]4[CH:37]=[CH:36][C:35]([CH2:38]Br)=[CH:34][CH:33]=4)=[CH:30][CH:29]=[C:28]([Cl:40])[CH:27]=3)=[N:24][N:23]=[N:22]2)C=CC=CC=1>>[CH3:1][C:2]1[N:7]=[C:6]2[N:8]([CH2:38][C:35]3[CH:34]=[CH:33][C:32]([C:31]4[CH:30]=[CH:29][C:28]([Cl:40])=[CH:27][C:26]=4[C:25]4[NH:21][N:22]=[N:23][N:24]=4)=[CH:37][CH:36]=3)[C:9]([CH2:11][CH3:12])=[N:10][C:5]2=[C:4]([CH3:13])[CH:3]=1.[ClH:40]

Participants

4

Reactant 2

HCID 98153742,6-Dimethyl-8-ethyl-1-deazapurineHCID 131717266HCID 131717266, compound

Product 2

HCID 313Hydrochloric AcidHCID 178437429HCID 178437429, compound

Procedure

The title compound was prepared from 5,7-dimethyl-2-ethylimidazo[4,5-b]pyridine and N-triphenylmethyl-5-(4'-bromomethyl-4-chlorobiphen-2-yl)tetrazole in a manner similar to Example 7, and was isolated as an HCl salt. 1H NMR (300 MHz, CD3OD) δ 1.38 (t, 3H), 2.72 (s, 6H), 3.28 (q, 2H), 5.8 2 (s, 7.8 (d, 2H), 7,36 (d, 2H), 7.44 (s, 1H), 7.58 (d, 1H), 7.72 (dd, 1H), 7.76 (d, 1H); FAB mass spectrum, m/e 444 (M+H, calcd for C24H22N7Cl, 444).

Sources & evidence

ORD record
ord-7a10605ed1f543a4b9a1c44feb106ede
Source dataset
uspto-grants-1994_07
Patent number
US05332744

Reaction notes

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