Benzene → HCID 12906807, compound

HRID 1729578Notes

Reaction equation

HRID 1729578 reaction equation
[CH3:1][C:2]1([CH3:7])[NH:6][CH2:5][CH2:4][S:3]1.C1C=CC=CC=1.[Br:14][CH:15]([Br:19])[C:16](Cl)=[O:17].C(N(CC)CC)C>O>[CH3:1][C:2]1([CH3:7])[N:6]([C:16](=[O:17])[CH:15]([Br:19])[Br:14])[CH2:5][CH2:4][S:3]1

Participants

6

Reactant 4

HCID 241BenzeneHCID 8471TriethylamineHCID 79184Dibromoacetyl chlorideHCID 880152,2-Dimethylthiazolidine

Product 1

HCID 12906807HCID 12906807, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 3.5 g. of 2,2-dimethyl thiazolidine, 50 ml. of benzene and 7.1 g. of dibromoacetyl chloride mixed in an ice bath was added 3.1 g. of triethylamine dropwise with stirring and continued cooling. When reaction was complete, the mixture was poured into water and the benzene layer separated, dried over magnesium sulfate and the benzene removed under vacuum. Yield was 8.5 g. of a dark oil.

Workup

  1. additionTo a mixture of 3.5 g
  2. additionwas added 3.1 g
  3. temperaturecontinued cooling
  4. customWhen reaction
  5. customthe benzene layer separated
  6. dry with materialdried over magnesium sulfate
  7. customthe benzene removed under vacuum

Sources & evidence

ORD record
ord-683d6c7f294c49fcb8b5e2468f1fc091
Source dataset
uspto-grants-1976_11
Patent number
US03989503

Reaction notes

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