反应详情

The mixture of 23.0 g of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1-benzazepine-2,5-dione-4-carboxylic acid methyl ester, 8.9 g of 2-aminothiazole and 360 ml of toluene is distilled for 20 hours so that after collecting 100 ml of toluene each, this amount is returned to the reaction mixture. It is finally concentrated to a volume of 150 ml, the resulting suspension cooled with ice, filtered and the residue recrystallized from chloroform-acetonitrile, to yield the 8-chloro-1-methyl-4-(2-thiazolylcarbamoyl)-2,3,4,5-tetrahydro-1-benzazepine-2,5-dione of the formula ##SPC3##

1. distillationis distilled for 20 hours so
2. customthat after collecting 100 ml of toluene each, this amount
3. concentrationIt is finally concentrated to a volume of 150 ml
4. temperaturethe resulting suspension cooled with ice
5. filtrationfiltered
6. customthe residue recrystallized from chloroform-acetonitrile