4-Phenyl-3-Buten-2-one → HCID 12391097, compound

HRID 1729686Notes

Reaction equation

HRID 1729686 reaction equation
[CH:1](=[CH:8][C:9](=O)[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:12]([O:14][C:15](=[O:20])[CH2:16][C:17](=[NH:19])[NH2:18])[CH3:13]>C(O)C>[CH2:12]([O:14][C:15]([C:16]1[CH:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:8]=[C:9]([CH3:10])[NH:19][C:17]=1[NH2:18])=[O:20])[CH3:13]

Participants

4

Reactant 2

HCID 159094-Phenyl-3-Buten-2-oneHCID 4599837Carbamimidoyl-acetic acid ethyl ester

Product 1

HCID 12391097HCID 12391097, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Boiling a solution of 14.6 g of benzylideneacetone and 13.0 g of amidinoacetic acid ethyl ester in 150 ml of ethanol for 2 hours yields 2-amino-6-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester of melting point 150°C (ethanol). Yield: 73 percent of theory.

Workup

  1. customfor 2 hours

Sources & evidence

ORD record
ord-5ee515c516564491a9ed0113e3e4b32a
Source dataset
uspto-grants-1976_11
Patent number
US03989708

Reaction notes

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