HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzylideneacetone → Ethyl 2-amino-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzylideneacetone | HCID 140760 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-amino-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3-carboxylate | HCID 193867 | 62% |
Reaction Steps
Upon boiling a solution of 18.1 g of 2-chlorobenzylideneacetone and 13.0 g of amidinoacetic acid ethyl ester in 150 ml of ethanol for 2 hours, 2-amino-6-methyl-4-(2-chlorophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester of melting point 171°C (ethanol) is obtained. Yield: 62 percent of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03989708 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-0b6573f82fd3413a8df7fabbea891dda |
| Source note | uspto-grants-1976_11 |