Isopropanol → HCID 68133965, compound

HRID 1729693Notes

Reaction equation

HRID 1729693 reaction equation
[CH3:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6](=O)[CH3:7].[CH2:13]([O:15][C:16](=[O:21])[CH2:17][C:18](=[NH:20])[NH2:19])[CH3:14].C(O)(C)C>C(O)C>[CH2:13]([O:15][C:16]([C:17]1[CH:4]([C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=2[CH3:1])[CH:5]=[C:6]([CH3:7])[NH:20][C:18]=1[NH2:19])=[O:21])[CH3:14]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 140152HCID 140152, compoundHCID 4599837Carbamimidoyl-acetic acid ethyl ester

Product 1

HCID 68133965HCID 68133965, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Upon heating a solution of 16.0 g of 2-methylbenzylideneacetone and 13.0 of amidinoacetic acid ethyl ester in 150 ml of ethanol for 2 hours, 2-amino-6-methyl-4-(2-methylphenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester of melting point 159°C (isopropanol) is obtained. Yield: 61 percent of theory.

Sources & evidence

ORD record
ord-7ef9d38fcc714b0092d4d5901ebafd9e
Source dataset
uspto-grants-1976_11
Patent number
US03989708

Reaction notes

Loading…