2-Chlorochalcone → HCID 12391102, compound

HRID 1729694Notes

Reaction equation

HRID 1729694 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH:4]=[CH:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.[CH2:18]([O:20][C:21](=[O:26])[CH2:22][C:23](=[NH:25])[NH2:24])[CH3:19]>C(O)C>[CH2:18]([O:20][C:21]([C:22]1[CH:4]([C:3]2[CH:14]=[CH:15][CH:16]=[CH:17][C:2]=2[Cl:1])[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[NH:24][C:23]=1[NH2:25])=[O:26])[CH3:19]

Participants

4

Reactant 2

HCID 979002-ChlorochalconeHCID 4599837Carbamimidoyl-acetic acid ethyl ester

Product 1

HCID 12391102HCID 12391102, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Upon boiling a solution of 24.3 g of 2-chlorobenzylideneacetophenone and 13.0 g of amidinoacetic acid ethyl ester in 250 ml of ethanol for 3 hours, 2-amino-6-phenyl-4-(2-chlorophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester of melting point 196°C (alcohol) is obtained. Yield: 68 percent of theory.

Workup

  1. customfor 3 hours

Sources & evidence

ORD record
ord-43afe77dfd7f4e93bce9df9677412abe
Source dataset
uspto-grants-1976_11
Patent number
US03989708

Reaction notes

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