HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 3-{[1-(4-Chlorophenyl)-1H-benzimidazol-2-yl]amino}propan-1-ol | HCID 21500321 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 21500333 | HCID 21500333 | — |
Reaction Steps
Thionychloride (5ml.) is added dropwise to a stirred solution of 2-(3-hydroxypropylamino)-1-(4-chlorophenyl)-benzimidazole (5.75 g.) in chloroform (50 ml.) and the solution is heated under reflux for 2 hours. On cooling and dilution with ether the title compound is obtained as its hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03989709 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-4140028872284a7dbd3dde36c2f3cebe |
| Source note | uspto-grants-1976_11 |