Diethyl Ether → Hydrochloric Acid

HRID 1729699Notes

Reaction equation

HRID 1729699 reaction equation
O[CH2:2][CH2:3][CH2:4][NH:5][C:6]1[N:10]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[C:9]2[CH:18]=[CH:19][CH:20]=[CH:21][C:8]=2[N:7]=1.CCOCC.C(Cl)(Cl)[Cl:28]>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([N:10]2[C:9]3[CH:18]=[CH:19][CH:20]=[CH:21][C:8]=3[N:7]=[C:6]2[NH:5][CH2:4][CH2:3][CH2:2][Cl:28])=[CH:12][CH:13]=1.[ClH:17]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6212ChloroformHCID 215003213-{[1-(4-Chlorophenyl)-1H-benzimidazol-2-yl]amino}propan-1-ol

Product 2

HCID 313Hydrochloric AcidHCID 21500333HCID 21500333, compound

Procedure

Thionychloride (5ml.) is added dropwise to a stirred solution of 2-(3-hydroxypropylamino)-1-(4-chlorophenyl)-benzimidazole (5.75 g.) in chloroform (50 ml.) and the solution is heated under reflux for 2 hours. On cooling and dilution with ether the title compound is obtained as its hydrochloride.

Workup

  1. temperaturethe solution is heated
  2. temperatureunder reflux for 2 hours
  3. temperatureOn cooling

Sources & evidence

ORD record
ord-4140028872284a7dbd3dde36c2f3cebe
Source dataset
uspto-grants-1976_11
Patent number
US03989709

Reaction notes

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