Sodium Methoxide → HCID 21500327, compound

HRID 1729700Notes

Reaction equation

HRID 1729700 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[NH:17][CH2:18][CH2:19][CH2:20]Cl)=[CH:4][CH:3]=1.C[O-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]3[CH2:20][CH2:19][CH2:18][N:17]=[C:9]23)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 21500333HCID 21500333, compound

Product 1

HCID 21500327HCID 21500327, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(4-Chlorophenyl)-2-(3-chloropropylamino)benzimidazole (5mM) is added to a stirred solution of sodium methoxide (0.01 mole) in methanol (50 ml.) and the mixture heated under reflux for 5 hours. After removal of the methanol the residue is diluted with water, extracted with chloroform and the combined extracts washed and dried over magnesium sulphate. Evaporation gives the title compound as an oil which affords a salt on treatment with a suitable acid in an anhydrous medium.

Workup

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 5 hours
  3. customAfter removal of the methanol the residue
  4. additionis diluted with water
  5. extractionextracted with chloroform
  6. washthe combined extracts washed
  7. dry with materialdried over magnesium sulphate
  8. customEvaporation

Sources & evidence

ORD record
ord-a116700aa2be437e87cc8feacd87bade
Source dataset
uspto-grants-1976_11
Patent number
US03989709

Reaction notes

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