Sodium Methoxide → HCID 21500327, compound

Participants

Reaction Steps

1-(4-Chlorophenyl)-2-(3-chloropropylamino)benzimidazole (5mM) is added to a stirred solution of sodium methoxide (0.01 mole) in methanol (50 ml.) and the mixture heated under reflux for 5 hours. After removal of the methanol the residue is diluted with water, extracted with chloroform and the combined extracts washed and dried over magnesium sulphate. Evaporation gives the title compound as an oil which affords a salt on treatment with a suitable acid in an anhydrous medium.

Provenance & Evidence