反应详情

A mixture of 12.8 parts of ethyl 4-(5-chloro-1,3-dihydro-3-methyl-2-oxo-2H-benzimidazol-1-yl)-1-piperidinecarboxylate, 20 parts of potassium hydroxide, 128 parts of 2-propanol and 2.5 parts of water is stirred and refluxed overnight. The reaction mixture is cooled and evaporated. Water is added to the residue and the product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is triturated in 2,2'-oxybispropane. The product is filtered off and dried, yielding 5-chloro-1,3-dihydro-3-methyl-1-(4-piperidinyl)-2H-benzimidazol-2-one; mp. 200.9° C.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture is cooled
3. customevaporated
4. additionWater is added to the residue
5. extractionthe product is extracted with trichloromethane
6. customThe extract is dried
7. filtrationfiltered
8. customevaporated
9. customThe residue is triturated in 2,2'-oxybispropane
10. filtrationThe product is filtered off
11. customdried